para-Selective CH Amidation of Simple Arenes with Nitriles
نویسندگان
چکیده
منابع مشابه
A simple base-mediated amidation of aldehydes with azides.
A practical and efficient amidation reaction involving aromatic aldehydes and various azides under mild conditions is described. A broad spectrum of functional groups was tolerated, and the amides were synthesized in moderate to excellent yields, presenting an attractive alternative to the currently available synthetic methods.
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We report here a new catalytic reaction in which, para-nitro azides are acylated by aldehydes to produce amides and molecular nitrogen in a single step. The transformation is believed to proceed via an electron transfer process mediated by the tert-butoxide ion, and catalysed by a thiazolium salt derived species.
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ژورنال
عنوان ژورنال: Advanced Synthesis & Catalysis
سال: 2015
ISSN: 1615-4150
DOI: 10.1002/adsc.201500651